Methods for studying synaptosomal copper release

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Methods for studying synaptosomal copper release.

Cu is thought to play an important role in the pathogenesis of several neurodegenerative diseases, such as Wilson's, Alzheimer's, and probably in prion protein diseases like Creutzfeld-Jakob's disease. Until now, no method existed to determine the concentration of this cation in vivo. Here, we present two possible approaches combined with a critical comparison of the results. The successful use...

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ژورنال

عنوان ژورنال: Journal of Neuroscience Methods

سال: 2003

ISSN: 0165-0270

DOI: 10.1016/s0165-0270(03)00173-0